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Article number

LN2006182

Product Description

Flt 1 Human, Mouse, Rat UNLB Antibody

Alternative names

FLT1, FLT, FRT, VEGFR1, Vascular endothelial growth factor receptor 1, VEGFR-1, Fms-like tyrosine kinase 1, FLT-1, Tyrosine-protein kinase FRT, Tyrosine-protein kinase receptor FLT, FLT, Vascular permeability factor receptor

Size

200 µL

Product Type

Polyclonal

Target

Flt 1

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

UNLB

Isotype

IgG

Immunogen

Synthesized peptide derived from human Flt-1 around the non-phosphorylation site of Y1048.

Concentration

1 mg/ml

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Applications

IHC, ELISA

Molecular Weight

180 kDa

Formulation

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Recommended Dilution

IHC 1:100-1:300, ELISA 1:10000

Storage Conditions

Store at -20°C, and avoid repeat freeze-thaw cycles.

Shipping Conditions

ICE

Extra information

N-glycosylated. Ubiquitinated after VEGFA-mediated autophosphorylation, leading to proteolytic degradation. Autophosphorylated on tyrosine residues upon ligand binding. Autophosphorylation occurs in trans, i.e. one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit. Phosphorylation at Tyr-1169 is important for interaction with PLCG. Phosphorylation at Tyr-1213 is important for interaction with PIK3R1, PTPN11, GRB2, and PLCG. Phosphorylation at Tyr-1333 is important for endocytosis and for interaction with CBL, NCK1 and CRK. Is probably dephosphorylated by PTPRB.

ProteinID

Vascular endothelial growth factor receptor 1, VEGFR-1, Fms-like tyrosine kinase 1, FLT-1, Tyrosine-protein kinase FRT, Tyrosine-protein kinase receptor FLT, FLT, Vascular permeability factor receptor

UNSPSC number

12352203