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Article number

LN2200426

Product Description

GH1 Human Rec. Protein

Alternative names

GH, GH-N, GH1, GHB5, GHN, Growth hormone 1, hGH-N, IGHD1B

Size

50 µg

Reactivity

Human

Source

E. Coli

Peptide sequence

Phe27-Phe217

Biological activity

Measured by its ability to promote proliferation of INS-1 cells.The ED50 for this effect is 0.3-1.2 ng/mL.

Purity

> 85 % as determined by reducing SDS-PAGE.

Molecular Weight

Predicted: 24.7 kDa

Formulation

Lyophilized from sterile PBS, pH 7.4

Endotoxin Level

Please contact us for more information.

Reconstitution Instructions

Please refer to the printed manual for detailed information.

Tags

N-His

Storage Conditions

Samples are stable for up to twelve months from date of receipt at -70℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

Shipping Conditions

RT

Background

The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation: an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the growth hormone locus. Mutations in or deletions of the gene lead to growth hormone deficiency and short stature.

Extra information

A DNA sequence encoding the human GH1 (P01241) (Phe27-Phe217) was expressed with a polyhistidine tag at the N-terminus.

Accession #

P01241

UNSPSC number

12352202