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Article number

LN0146193

Product Description

PDZD3 Human UNLB Antibody

Alternative names

Na(+)/H(+) exchange regulatory cofactor NHE-RF4, NHERF-4, Intestinal and kidney-enriched PDZ protein, Natrium-phosphate cotransporter IIa C-terminal-associated protein 2, Na/Pi cotransporter C-terminal-associated protein 2, NaPi-Cap2, PDZ domain-containing protein 2, PDZ domain-containing protein 3, Sodium-hydrogen exchanger regulatory factor 4, PDZD3, IKEPP, NHERF4, PDZK2

Size

400 ul

Product Type

Polyclonal

Target

PDZD3

Reactivity

Human

Host

Rabbit

Conjugate

UNLB

Isotype

Ig

Immunogen

This PDZD3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 258-285 amino acids from the Central region of human PDZD3.

Concentration

0.5 mg/ml

Purification

This antibody is purified through a protein A column, followed by peptide affinity purification.

Applications

WB

Buffer

Supplied in PBS with 0.09% (W/V) sodium azide.

Molecular Weight

61 kDa

Physical State

Liquid

Recommended Dilution

For WB starting dilution is: 1:1000

Storage Conditions

Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Shipping Conditions

ICE

Background

Guanylyl cyclase C (GCC, or GUCY2C: MIM 601330) produces cGMP following the binding of either endogenous ligands or heat-stable enterotoxins secreted by E. coli and other enteric bacteria. Activation of GCC initiates a signaling cascade that leads to phosphorylation of the cystic fibrosis transmembrane conductance regulator (CFTR: MIM 602421), followed by a net efflux of ions and water into the intestinal lumen. IKEPP is a regulatory protein that associates with GCC and regulates the amount of cGMP produced following receptor stimulation (Scott et al., 2002 [PubMed 11950846]).

Protein GI #

308153467

Accession #

Q86UT5

NCBI GENE ID #

79849

NCBI OFFICIAL SYMBOL

PDZD3

NCBI OFFICIAL FULL NAME

Na(+)/H(+) exchange regulatory cofactor NHE-RF4

NCBI ORGANISM

Homo sapiens

SWISSPROT #

Q86UT5

UNSPSC number

12352203